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How do ageing mitochondria work and communicate differently?
Prof Luminita Paraoan, Manchester Metropolitan University - £230,270
Mitochondria are vital parts of every cell. They create the energy that cells need to survive and carry out tasks. The important layer of cells in the back of the eye called the retinal pigment epithelium (RPE) requires a large amount of energy, so the mitochondria can get stressed. Over time and with age these mitochondria get damaged, and we see higher amounts of damage in patients with AMD. This work aims to understand what happens to these mitochondria when they age and get damaged, how we could slow or stop this damage and whether that could slow or stop the progression of AMD.
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